New mental health research focusing on women has revealed how different the risk of depression is compared to men.
There are treatments for it, but these treatments are sometimes found to be ineffective. It addition, women are said to be more prone to depression than men. The reason for this difference is unknown. This sometimes makes diseases more difficult to treat.
The discoveries of the review were distributed for the current month in the diary Biological Psychiatry. University of California Davis, Researchers at Mt. Princeton University at Sinai Hospital; In collaboration with scientists from Quebec, they try to understand how a specific part of the brain, the nucleus accumbens, is affected during it.
The nucleus accumbens is important for motivation. Experiences and social interactions to reward responses are all effects of depression. Analyzes within the nucleus accumbens showed different genes. It was shown that depression was induced in women but not in men.
Other words, the experience of depression can change the brain. In order to differentiate depression-related behavior in females over males, the researchers studied rats exposed to more reinforcing negative social interactions.
In our mouse model, “Negative social interaction altered the genetic makeup of female mice found in depressed women,” said Alexia Williams. A recent postdoctoral researcher, a UC Davis graduate, designed and led the studies.
This discovery brings attention to the relevance of this information to women’s health.” Comparative analysis in the study identifies the nucleus. RGS2 identified as a key mediator of depression-related behavior.
The researchers identified similar molecular changes in the brains of mice and humans and then chose a gene called G protein signaling-2, or Rgs2, to manipulate. This gene is targeted by antidepressants such as Prozac and Zoloft. Controls the expression of proteins that regulate neurotransmitter receptors.
“Low levels of Rgs2 protein are associated with increased risk of depression in humans.” Thus, increasing Rgs2 in the nucleus accumbens can reduce depression-related behaviors, said Brian Trainor of UC Davis, professor of psychology and senior author.
He is an associate professor with the Department of Neuroscience and directs the Behavioral Neuroendocrinology Lab at UC Davis.